48+ Laughter Is The Best Medicine Quote Origin. However, others have postulated earlier origins for the phrase 'laughter is the best medicine'. Laughter is the physiological response to . Studies of laughter in interaction. The saying "laughter is the best medicine" is believed to have originated — albeit now in a snappier form —from proverbs 17.22 of the king . "laughter is the best medicine." we may never know where this quote originated, but it's a good one. Another postulation is that in the 1300s, henri . The benefits of a loud, robust belly . I have a soft spot for medical aphorisms. Yes, "laughter is the best medicine" is cliché and the phrase has likely lost some of the oomph it once had, but when you consider the origin as well as the . Some attribute the origin of this phrase to the american publisher and humor writer bennett cerf.